Introduction

Amyloidosis is a rare disease that occurs when an abnormal protein, called amyloid, builds up in your organs and tissues. Amyloid deposits can affect different organs in different people, and there is no one-size-fits-all description of what it feels like to have amyloidosis.

The buildup of amyloid can make it difficult for your organs and tissues to work properly. If too much amyloid builds up, organ failure can occur. Amyloidosis can affect the heart, kidneys, liver, spleen, nervous system, and digestive tract.

Symptoms of Amyloidosis

The symptoms of amyloidosis vary depending on which organs are affected. Some people with amyloidosis have no symptoms, while others have mild to severe symptoms. Common symptoms include:

• Fatigue
• Shortness of breath
• Swelling in the legs and ankles
• Numbness or tingling in the hands or feet
• Unexplained weight loss
• Diarrhea or constipation
• Enlarged tongue
• Skin changes, such as easy bruising or purplish patches around the eyes

Types of Amyloidosis

There are many different types of amyloidosis. Some of the most common types include:

• AL amyloidosis (primary amyloidosis): This type is caused by a problem with the bone marrow cells that produce antibodies.
• AA amyloidosis (secondary amyloidosis): This type is caused by chronic infections or inflammatory diseases, such as rheumatoid arthritis.
• Hereditary amyloidosis: This type is caused by a gene mutation that is passed down in families.

Treatment for Amyloidosis

There is no cure for amyloidosis, but treatments can help manage the symptoms and slow the progression of the disease. Treatment options vary depending on the type of amyloidosis and the organs that are affected. Some common treatments include:

• Chemotherapy
• Stem cell transplantation
• Supportive care, such as pain medication and dialysis

Living with Amyloidosis

Living with amyloidosis can be challenging, but there are ways to cope with the disease and maintain a good quality of life. It is important to:

• See your doctor regularly for checkups.
• Follow your treatment plan carefully.
• Eat a healthy diet and exercise regularly.
• Join a support group to connect with others who understand what you are going through.
• Educate yourself about amyloidosis so you can make informed decisions about your care.